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Target Snapshot

CHEMBL4530 Target Snapshot

Coagulation factor XIII A chain · SINGLE PROTEIN · Homo sapiens

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252Compounds
42Assays
0Approved Drugs
243.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Coagulation factor XIII A chain shows approved-linked disease relevance led by hemorrhage. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P00488. Start with hemorrhage, then reuse UniProt P00488 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with hemorrhage, then reuse UniProt P00488 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
hemorrhage

Coagulation factor XIII A chain shows approved-linked disease relevance led by hemorrhage. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with hemorrhage because it currently carries approved-linked support. Linked drugs include CATRIDECACOG. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Coagulation factor XIII A chain as ChEMBL target CHEMBL4530, mapped to UniProt P00488. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Coagulation factor XIII A chain
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4530
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P00488
Coagulation factor XIII A chain
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Coagulation factor XIII A chain is the right protein anchor across sources, using UniProt P00488 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why hemorrhage is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCoagulation factor XIII A chain
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP00488
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCoagulation factor XIII A chain
UniProt AccessionP00488
Component TypeProtein
Sequence Length732 aa

Coagulation factor XIII A chain

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Coagulation factor XIII A chain, mapped to UniProt P00488. Sequence length is 732 aa.

Mapped IDP00488
Review nameCoagulation factor XIII A chain
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Coagulation factor XIII A chain shows approved-linked disease relevance led by hemorrhage. 3 more disease programs remain visible in the same review block.

Approved-linked Approved
hemorrhage
1 linked drug · 1 direct · 1 efficacy
Linked drugCATRIDECACOG
Approved-linked Approved
Rare genetic coagulation disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugCATRIDECACOG
Late clinical Phase III
congenital factor XIII deficiency
1 linked drug · 1 direct · 1 efficacy
Linked drugCATRIDECACOG
Clinical signal Phase II
hemorrhagic disease
1 linked drug · 1 direct · 1 efficacy
Linked drugCATRIDECACOG
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with hemorrhage because it currently carries approved-linked support. Linked drugs include CATRIDECACOG. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasehemorrhage
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC50235.0
KI5.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3423195 8.4 IC50 4.0 Preclinical
CHEMBL3423198 8.4 IC50 4.0 Preclinical
CHEMBL5912424 8.0 IC50 10.0 Preclinical
CHEMBL5872808 7.96 IC50 11.0 Preclinical
CHEMBL5932274 7.92 IC50 12.0 Preclinical
CHEMBL6009354 7.89 IC50 13.0 Preclinical
CHEMBL6019101 7.82 IC50 15.0 Preclinical
CHEMBL5803781 7.8 IC50 16.0 Preclinical
CHEMBL5958971 7.8 IC50 16.0 Preclinical
CHEMBL5842415 7.77 IC50 17.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
19
5.5
45
6.0
38
6.5
30
7.0
20
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

42
Total Assays
182
Tested Compounds
1
Assay Types
Binding — 42 assays, 182 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 39 176 6.4
cell-free format 3 6 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine