Phosphotyrosine-protein phosphatase PTPB · SINGLE PROTEIN · Mycobacterium tuberculosis
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As of 2026-09-14Protein identity stays anchored to UniProt P96830. Use UniProt P96830 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P96830 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine specific protein phosphatases domain-containing protein
Review this target as Phosphotyrosine-protein phosphatase PTPB, mapped to UniProt P96830. ChEMBL maps the protein component as Tyrosine specific protein phosphatases domain-containing protein. Sequence length is 276 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphotyrosine-protein phosphatase PTPB as ChEMBL target CHEMBL4540, mapped to UniProt P96830. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Phosphotyrosine-protein phosphatase PTPB is the right protein anchor across sources, using UniProt P96830 as the stable mapping.
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| Preferred Name | Phosphotyrosine-protein phosphatase PTPB |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
| UniProt | P96830 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine specific protein phosphatases domain-containing protein |
| UniProt Accession | P96830 |
| Component Type | Protein |
| Sequence Length | 276 aa |
Tyrosine specific protein phosphatases domain-containing protein
Review this target as Phosphotyrosine-protein phosphatase PTPB, mapped to UniProt P96830. ChEMBL maps the protein component as Tyrosine specific protein phosphatases domain-containing protein. Sequence length is 276 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4647367 | 8.19 | IC50 | 6.4 | Preclinical |
| CHEMBL3769851 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL2316902 | 7.42 | IC50 | 38.0 | Preclinical |
| CHEMBL1765363 | 6.82 | Ki | 150.0 | Preclinical |
| CHEMBL1765362 | 6.66 | IC50 | 220.0 | Preclinical |
| CHEMBL1765362 | 6.66 | Ki | 220.0 | Preclinical |
| CHEMBL1765366 | 6.6 | Ki | 250.0 | Preclinical |
| CHEMBL1765366 | 6.5 | IC50 | 320.0 | Preclinical |
| CHEMBL368885 | 6.44 | IC50 | 360.0 | Preclinical |
| CHEMBL178884 | 6.37 | IC50 | 430.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 18 | 53 | 5.3 |
| assay format | 11 | 14 | 5.4 |
| cell-based format | 4 | 0 | — |