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Target Snapshot

CHEMBL4542 Target Snapshot

Low molecular weight protein-tyrosine phosphatase A · SINGLE PROTEIN · Mycobacterium tuberculosis

295Compounds
36Assays
0Approved Drugs
215.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P9WIA1. Use UniProt P9WIA1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P9WIA1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Low molecular weight protein-tyrosine phosphatase A as ChEMBL target CHEMBL4542, mapped to UniProt P9WIA1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Low molecular weight protein-tyrosine phosphatase A
SINGLE PROTEIN · Mycobacterium tuberculosis
As of 2026-09-14
ChEMBL target ID
CHEMBL4542
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P9WIA1
Low molecular weight protein-tyrosine phosphatase A
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Low molecular weight protein-tyrosine phosphatase A is the right protein anchor across sources, using UniProt P9WIA1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLow molecular weight protein-tyrosine phosphatase A
UniProt AccessionP9WIA1
Component TypeProtein
Sequence Length163 aa

Low molecular weight protein-tyrosine phosphatase A

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Low molecular weight protein-tyrosine phosphatase A, mapped to UniProt P9WIA1. Sequence length is 163 aa.

Mapped IDP9WIA1
Review nameLow molecular weight protein-tyrosine phosphatase A
OrganismMycobacterium tuberculosis
Assay Mix

Activity Type Distribution

IC50148.0
KI67.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2316908 6.16 IC50 700.0 Preclinical
CHEMBL4638054 6.1 Ki 800.0 Preclinical
CHEMBL1765359 6.05 IC50 900.0 Preclinical
CHEMBL2316905 5.96 IC50 1100.0 Preclinical
CHEMBL4292242 5.92 Ki 1200.0 Preclinical
CHEMBL1081579 5.85 Ki 1400.0 Preclinical
CHEMBL4290098 5.83 IC50 1490.0 Preclinical
CHEMBL1765360 5.8 Ki 1600.0 Preclinical
CHEMBL2316906 5.8 IC50 1600.0 Preclinical
CHEMBL4288744 5.77 Ki 1700.0 Preclinical
Distribution

pChEMBL Value Distribution

27
5.0
15
5.5
3
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

37
Total Assays
110
Tested Compounds
1
Assay Types
Binding — 37 assays, 110 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 31 92 4.8
assay format 6 18 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine