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Target Snapshot

CHEMBL4554 Target Snapshot

Substance-K receptor · SINGLE PROTEIN · Rattus norvegicus

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302Compounds
50Assays
0Approved Drugs
186.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P16610. Use UniProt P16610 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P16610 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Substance-K receptor as ChEMBL target CHEMBL4554, mapped to UniProt P16610. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Substance-K receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL4554
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P16610
Substance-K receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Substance-K receptor is the right protein anchor across sources, using UniProt P16610 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSubstance-K receptor
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP16610
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSubstance-K receptor
UniProt AccessionP16610
Component TypeProtein
Sequence Length390 aa

Substance-K receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Substance-K receptor, mapped to UniProt P16610. Sequence length is 390 aa.

Mapped IDP16610
Review nameSubstance-K receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5039.0
KI57.0
EC5046.0
KD44.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2110370 10.0 Ki 0.1 Preclinical
CHEMBL16180 9.65 Kd 0.2239 Preclinical
CHEMBL368995 9.52 Ki 0.3 Preclinical
CHEMBL173203 9.52 Ki 0.3 Preclinical
CHEMBL59413 9.5 Ki 0.3162 Preclinical
CHEMBL301477 9.4 EC50 0.4 Preclinical
CHEMBL301841 9.4 EC50 0.4 Preclinical
CHEMBL308148 9.3 Ki 0.5 Clinical
CHEMBL60064 9.3 Ki 0.5012 Preclinical
CHEMBL346178 9.29 Ki 0.51 Clinical
Distribution

pChEMBL Value Distribution

11
5.0
13
5.5
23
6.0
23
6.5
21
7.0
16
7.5
23
8.0
12
8.5
11
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

50
Total Assays
102
Tested Compounds
2
Assay Types
Functional — 33 assays, 55 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 13 44 6.6
tissue-based format 12 10 8.1
cell-based format 8 1 8.2
Binding — 17 assays, 102 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 23 6.4
cell membrane format 4 35 7.1
cell-based format 3 4 6.6
single protein format 3 37 7.7
tissue-based format 1 3 8.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine