Neuropeptide Y receptor type 5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Neuropeptide Y receptor type 5 shows late clinical disease relevance led by obesity. 1 more disease program remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q15761. Start with obesity, then reuse UniProt Q15761 as the stable protein anchor across project notes and exports.
Start with obesity, then reuse UniProt Q15761 as the stable protein anchor across project notes and exports.
Neuropeptide Y receptor type 5 shows late clinical disease relevance led by obesity. 1 more disease program remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with obesity because it currently carries late clinical support. Linked drugs include MK-0557, VELNEPERIT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyNeuropeptide Y receptor type 5
Review this target as Neuropeptide Y receptor type 5, mapped to UniProt Q15761. Sequence length is 445 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuropeptide Y receptor type 5 as ChEMBL target CHEMBL4561, mapped to UniProt Q15761. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Neuropeptide Y receptor type 5 is the right protein anchor across sources, using UniProt Q15761 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why obesity is currently framed as late clinical support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Neuropeptide Y receptor type 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15761 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuropeptide Y receptor type 5 |
| UniProt Accession | Q15761 |
| Component Type | Protein |
| Sequence Length | 445 aa |
Neuropeptide Y receptor type 5
Review this target as Neuropeptide Y receptor type 5, mapped to UniProt Q15761. Sequence length is 445 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Neuropeptide Y receptor type 5 shows late clinical disease relevance led by obesity. 1 more disease program remain visible in the same review block.
Start review with obesity because it currently carries late clinical support. Linked drugs include MK-0557, VELNEPERIT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1257993 | 10.6 | Ki | 0.02512 | Preclinical |
| CHEMBL1258111 | 10.5 | Ki | 0.03162 | Preclinical |
| CHEMBL1258225 | 10.4 | Ki | 0.03981 | Preclinical |
| CHEMBL1257992 | 10.2 | Ki | 0.0631 | Preclinical |
| CHEMBL1258341 | 10.2 | Ki | 0.0631 | Preclinical |
| CHEMBL1258787 | 10.2 | Ki | 0.0631 | Preclinical |
| CHEMBL1258110 | 10.1 | Ki | 0.07943 | Preclinical |
| CHEMBL1257636 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL1258340 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL1258453 | 10.0 | Ki | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 57 | 614 | 7.5 |
| single protein format | 35 | 423 | 7.6 |
| assay format | 3 | 18 | 7.4 |
| cell membrane format | 1 | 18 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 24 | 142 | 7.8 |
| assay format | 12 | 52 | 8.7 |