Maternal embryonic leucine zipper kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Protein identity stays anchored to UniProt Q14680. Use UniProt Q14680 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14680 as the stable identity anchor, then attach disease evidence before program review.
Maternal embryonic leucine zipper kinase
Review this target as Maternal embryonic leucine zipper kinase, mapped to UniProt Q14680. Sequence length is 651 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Maternal embryonic leucine zipper kinase as ChEMBL target CHEMBL4578, mapped to UniProt Q14680. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Maternal embryonic leucine zipper kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14680 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Maternal embryonic leucine zipper kinase |
| UniProt Accession | Q14680 |
| Component Type | Protein |
| Sequence Length | 651 aa |
Maternal embryonic leucine zipper kinase
Review this target as Maternal embryonic leucine zipper kinase, mapped to UniProt Q14680. Sequence length is 651 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4077934 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL3688335 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3688376 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3824328 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL1980995 | 9.5 | Ki | 0.3162 | Preclinical |
| CHEMBL4062168 | 9.41 | Ki | 0.39 | Preclinical |
| CHEMBL3688339 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3692787 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3692824 | 9.34 | IC50 | 0.46 | Preclinical |
| CHEMBL1908392 | 9.33 | Ki | 0.47 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 308 | 830 | 7.9 |
| assay format | 42 | 33 | 6.7 |
| cell-based format | 23 | 22 | 7.3 |
| subcellular format | 5 | 31 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 193 | 6.6 |
| cell-based format | 1 | 0 | — |