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Target Snapshot

CHEMBL4586 Target Snapshot

Seed linoleate 13S-lipoxygenase-1 · SINGLE PROTEIN · Glycine max

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304Compounds
94Assays
0Approved Drugs
235.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P08170. Use UniProt P08170 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P08170 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Seed linoleate 13S-lipoxygenase-1 as ChEMBL target CHEMBL4586, mapped to UniProt P08170. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Seed linoleate 13S-lipoxygenase-1
SINGLE PROTEIN · Glycine max
As of 2026-09-13
ChEMBL target ID
CHEMBL4586
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08170
Seed linoleate 13S-lipoxygenase-1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Seed linoleate 13S-lipoxygenase-1 is the right protein anchor across sources, using UniProt P08170 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSeed linoleate 13S-lipoxygenase-1
Target TypeSINGLE PROTEIN
OrganismGlycine max
UniProtP08170
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSeed linoleate 13S-lipoxygenase-1
UniProt AccessionP08170
Component TypeProtein
Sequence Length839 aa

Seed linoleate 13S-lipoxygenase-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Seed linoleate 13S-lipoxygenase-1, mapped to UniProt P08170. Sequence length is 839 aa.

Mapped IDP08170
Review nameSeed linoleate 13S-lipoxygenase-1
OrganismGlycine max
Clinical Profile

Clinical Phase Distribution

1
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC50205.0
KI30.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL89283 7.24 IC50 57.0 Preclinical
CHEMBL314941 7.19 IC50 65.0 Preclinical
CHEMBL372548 7.0 IC50 100.0 Preclinical
CHEMBL88952 6.85 IC50 140.0 Preclinical
CHEMBL92212 6.85 IC50 140.0 Preclinical
CHEMBL316139 6.77 IC50 170.0 Preclinical
CHEMBL52 6.75 IC50 180.0 Preclinical
CHEMBL2296824 6.72 Ki 192.0 Preclinical
CHEMBL437540 6.7 Ki 198.0 Preclinical
CHEMBL194297 6.52 IC50 300.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
16
5.5
15
6.0
14
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

94
Total Assays
146
Tested Compounds
2
Assay Types
Binding — 83 assays, 146 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 83 146 5.0
Functional — 11 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 11 3 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine