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Target Snapshot

CHEMBL4595 Target Snapshot

Lysophosphatidic acid receptor 1 · SINGLE PROTEIN · Rattus norvegicus

32Compounds
13Assays
0Approved Drugs
41.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P61794. Use UniProt P61794 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P61794 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lysophosphatidic acid receptor 1 as ChEMBL target CHEMBL4595, mapped to UniProt P61794. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lysophosphatidic acid receptor 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL4595
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P61794
Lysophosphatidic acid receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lysophosphatidic acid receptor 1 is the right protein anchor across sources, using UniProt P61794 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLysophosphatidic acid receptor 1
UniProt AccessionP61794
Component TypeProtein
Sequence Length364 aa

Lysophosphatidic acid receptor 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lysophosphatidic acid receptor 1, mapped to UniProt P61794. Sequence length is 364 aa.

Mapped IDP61794
Review nameLysophosphatidic acid receptor 1
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC5024.0
KI3.0
EC5014.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL247959 7.54 IC50 29.0 Preclinical
CHEMBL4871014 7.33 IC50 47.0 Preclinical
CHEMBL246929 7.32 IC50 48.0 Preclinical
CHEMBL246943 7.25 IC50 56.0 Preclinical
CHEMBL246527 7.14 IC50 72.0 Preclinical
CHEMBL246735 7.14 IC50 73.0 Preclinical
CHEMBL245295 7.13 IC50 74.0 Preclinical
CHEMBL246928 7.09 IC50 81.0 Preclinical
CHEMBL246942 7.0 IC50 100.0 Preclinical
CHEMBL394038 6.96 IC50 110.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
6
5.5
4
6.0
3
6.5
8
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

13
Total Assays
11
Tested Compounds
2
Assay Types
Binding — 7 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 0
cell-based format 2 9 5.8
cell-free format 1 1 7.3
Functional — 6 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 0
assay format 2 0
cell-based format 1 11 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine