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Target Snapshot

CHEMBL4602 Target Snapshot

Ephrin type-A receptor 7 · SINGLE PROTEIN · Homo sapiens

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779Compounds
228Assays
8Approved Drugs
377.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q15375. Use UniProt Q15375 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q15375 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ephrin type-A receptor 7 as ChEMBL target CHEMBL4602, mapped to UniProt Q15375. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ephrin type-A receptor 7
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4602
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q15375
Ephrin type-A receptor 7
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ephrin type-A receptor 7 is the right protein anchor across sources, using UniProt Q15375 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameEphrin type-A receptor 7
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ15375
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEphrin type-A receptor 7
UniProt AccessionQ15375
Component TypeProtein
Sequence Length998 aa

Ephrin type-A receptor 7

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Ephrin type-A receptor 7, mapped to UniProt Q15375. Sequence length is 998 aa.

Mapped IDQ15375
Review nameEphrin type-A receptor 7
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
6
Phase III
10
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC5027.0
EC501.0
KD349.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5423601 8.75 IC50 1.77 Preclinical
CHEMBL1230609 8.6 Kd 2.5 Clinical
CHEMBL1784637 8.38 IC50 4.2 Preclinical
CHEMBL495727 8.1 Kd 8.0 Clinical
CHEMBL3688339 7.8 Kd 16.0 Preclinical
CHEMBL3545085 7.77 Kd 17.0 Preclinical
CHEMBL3544983 7.66 Kd 22.0 Clinical
CHEMBL388978 7.41 IC50 39.2 Preclinical
CHEMBL475251 7.41 Kd 39.0 Clinical
CHEMBL402548 7.4 Kd 40.0 Clinical
Distribution

pChEMBL Value Distribution

10
5.0
20
5.5
21
6.0
11
6.5
7
7.0
3
7.5
3
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
Assay Landscape

Assay Landscape

228
Total Assays
56
Tested Compounds
1
Assay Types
Binding — 228 assays, 56 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 179 40 6.2
assay format 27 2 6.5
cell-based format 11 2 6.1
subcellular format 11 12 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine