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Target Snapshot

CHEMBL4603 Target Snapshot

Beta-galactosidase · SINGLE PROTEIN · Escherichia coli K-12

85Compounds
9Assays
0Approved Drugs
19.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P00722. Use UniProt P00722 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00722 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-galactosidase as ChEMBL target CHEMBL4603, mapped to UniProt P00722. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-galactosidase
SINGLE PROTEIN · Escherichia coli K-12
As of 2026-09-14
ChEMBL target ID
CHEMBL4603
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P00722
Beta-galactosidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-galactosidase is the right protein anchor across sources, using UniProt P00722 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-galactosidase
UniProt AccessionP00722
Component TypeProtein
Sequence Length1024 aa

Beta-galactosidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Beta-galactosidase, mapped to UniProt P00722. Sequence length is 1024 aa.

Mapped IDP00722
Review nameBeta-galactosidase
OrganismEscherichia coli K-12
Assay Mix

Activity Type Distribution

IC5014.0
KI5.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL205982 6.66 Ki 220.0 Preclinical
CHEMBL1911831 6.57 Ki 270.0 Preclinical
CHEMBL406973 5.37 Ki 4300.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
2
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 9 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 3 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine