Glutamine synthetase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P15104. Use UniProt P15104 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P15104 as the stable identity anchor, then attach disease evidence before program review.
Glutamine synthetase
Review this target as Glutamine synthetase, mapped to UniProt P15104. Sequence length is 373 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamine synthetase as ChEMBL target CHEMBL4612, mapped to UniProt P15104. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Glutamine synthetase is the right protein anchor across sources, using UniProt P15104 as the stable mapping.
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| Preferred Name | Glutamine synthetase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P15104 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamine synthetase |
| UniProt Accession | P15104 |
| Component Type | Protein |
| Sequence Length | 373 aa |
Glutamine synthetase
Review this target as Glutamine synthetase, mapped to UniProt P15104. Sequence length is 373 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL310570 | 7.85 | EC50 | 14.2 | Preclinical |
| CHEMBL131 | 7.5 | EC50 | 32.0 | Approved |
| CHEMBL83110 | 7.42 | EC50 | 37.7 | Preclinical |
| CHEMBL82546 | 7.27 | EC50 | 53.7 | Preclinical |
| CHEMBL312399 | 7.18 | EC50 | 66.0 | Preclinical |
| CHEMBL309243 | 7.18 | EC50 | 66.0 | Preclinical |
| CHEMBL311662 | 6.89 | EC50 | 129.2 | Preclinical |
| CHEMBL312041 | 6.74 | EC50 | 181.6 | Preclinical |
| CHEMBL3142429 | 6.07 | Ki | 850.0 | Preclinical |
| CHEMBL1160314 | 4.12 | Ki | 75000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 32 | 2 | 5.1 |
| assay format | 10 | 0 | — |
| cell-based format | 2 | 8 | 7.2 |
| tissue-based format | 1 | 1 | — |