Bifunctional dihydrofolate reductase-thymidylate synthase · SINGLE PROTEIN · Leishmania major
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As of 2026-09-13Protein identity stays anchored to UniProt P07382. Use UniProt P07382 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07382 as the stable identity anchor, then attach disease evidence before program review.
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt P07382. Sequence length is 520 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bifunctional dihydrofolate reductase-thymidylate synthase as ChEMBL target CHEMBL4614, mapped to UniProt P07382. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Bifunctional dihydrofolate reductase-thymidylate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Leishmania major |
| UniProt | P07382 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bifunctional dihydrofolate reductase-thymidylate synthase |
| UniProt Accession | P07382 |
| Component Type | Protein |
| Sequence Length | 520 aa |
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt P07382. Sequence length is 520 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL34259 | 9.89 | Ki | 0.1288 | Approved |
| CHEMBL34259 | 8.64 | IC50 | 2.29 | Approved |
| CHEMBL6054471 | 8.43 | IC50 | 3.72 | Preclinical |
| CHEMBL4544467 | 8.13 | IC50 | 7.41 | Preclinical |
| CHEMBL4456834 | 8.12 | IC50 | 7.59 | Preclinical |
| CHEMBL5786336 | 8.1 | IC50 | 7.94 | Preclinical |
| CHEMBL20424 | 7.77 | Ki | 16.98 | Preclinical |
| CHEMBL20587 | 7.68 | Ki | 20.89 | Preclinical |
| CHEMBL533684 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL5759188 | 7.54 | IC50 | 28.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 87 | 6.3 |
| cell-based format | 1 | 34 | 5.6 |