Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q14123. Use UniProt Q14123 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14123 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Review this target as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, mapped to UniProt Q14123. Sequence length is 709 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C as ChEMBL target CHEMBL4619, mapped to UniProt Q14123. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14123 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| UniProt Accession | Q14123 |
| Component Type | Protein |
| Sequence Length | 709 aa |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Review this target as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, mapped to UniProt Q14123. Sequence length is 709 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5572993 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL572934 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5977186 | 9.4 | IC50 | 0.396 | Preclinical |
| CHEMBL6057973 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL6005179 | 9.39 | IC50 | 0.406 | Preclinical |
| CHEMBL6042932 | 9.38 | IC50 | 0.419 | Preclinical |
| CHEMBL5856741 | 9.34 | IC50 | 0.46 | Preclinical |
| CHEMBL5990945 | 9.34 | IC50 | 0.46 | Preclinical |
| CHEMBL6062258 | 9.34 | IC50 | 0.46 | Preclinical |
| CHEMBL5843142 | 9.28 | IC50 | 0.52 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 51 | 648 | 7.3 |
| cell-based format | 15 | 30 | 6.5 |
| assay format | 6 | 25 | 7.3 |
| tissue-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |