Bcl-2-like protein 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Bcl-2-like protein 1 shows late clinical disease relevance led by small cell lung carcinoma. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q07817. Start with small cell lung carcinoma, then reuse UniProt Q07817 as the stable protein anchor across project notes and exports.
Start with small cell lung carcinoma, then reuse UniProt Q07817 as the stable protein anchor across project notes and exports.
Bcl-2-like protein 1 shows late clinical disease relevance led by small cell lung carcinoma. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with small cell lung carcinoma because it currently carries late clinical support. Linked drugs include NAVITOCLAX, OBATOCLAX MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyBcl-2-like protein 1
Review this target as Bcl-2-like protein 1, mapped to UniProt Q07817. Sequence length is 233 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bcl-2-like protein 1 as ChEMBL target CHEMBL4625, mapped to UniProt Q07817. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Bcl-2-like protein 1 is the right protein anchor across sources, using UniProt Q07817 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why small cell lung carcinoma is currently framed as late clinical support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Bcl-2-like protein 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q07817 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bcl-2-like protein 1 |
| UniProt Accession | Q07817 |
| Component Type | Protein |
| Sequence Length | 233 aa |
Bcl-2-like protein 1
Review this target as Bcl-2-like protein 1, mapped to UniProt Q07817. Sequence length is 233 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Bcl-2-like protein 1 shows late clinical disease relevance led by small cell lung carcinoma. 5 more disease programs remain visible in the same review block.
Start review with small cell lung carcinoma because it currently carries late clinical support. Linked drugs include NAVITOCLAX, OBATOCLAX MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3342333 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL3342197 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3935328 | 10.57 | Ki | 0.027 | Preclinical |
| CHEMBL3342196 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3342334 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3926447 | 10.41 | Ki | 0.039 | Preclinical |
| CHEMBL3699077 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL3342198 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL3342192 | 10.38 | Ki | 0.042 | Preclinical |
| CHEMBL3891330 | 10.36 | Ki | 0.044 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 224 | 1,281 | 6.5 |
| cell-based format | 71 | 92 | 7.6 |
| assay format | 40 | 274 | 7.3 |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 0 | — |
| assay format | 6 | 66 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 31 | 6.6 |