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Target Snapshot

CHEMBL4627242 Target Snapshot

L-lactate dehydrogenase A chain mRNA · NUCLEIC-ACID · Homo sapiens

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

L-lactate dehydrogenase A chain mRNA shows approved-linked disease relevance led by primary hyperoxaluria. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt ENSG00000134333. Start with primary hyperoxaluria, then reuse UniProt ENSG00000134333 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with primary hyperoxaluria, then reuse UniProt ENSG00000134333 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
primary hyperoxaluria

L-lactate dehydrogenase A chain mRNA shows approved-linked disease relevance led by primary hyperoxaluria. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with primary hyperoxaluria because it currently carries approved-linked support. Linked drugs include NEDOSIRAN SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats L-lactate dehydrogenase A chain mRNA as ChEMBL target CHEMBL4627242, mapped to UniProt ENSG00000134333. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L-lactate dehydrogenase A chain mRNA
NUCLEIC-ACID · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4627242
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
ENSG00000134333
L-lactate dehydrogenase A chain mRNA
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether L-lactate dehydrogenase A chain mRNA is the right protein anchor across sources, using UniProt ENSG00000134333 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why primary hyperoxaluria is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelL-lactate dehydrogenase A chain mRNA
UniProt AccessionENSG00000134333
Component TypeRna

L-lactate dehydrogenase A chain mRNA

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as L-lactate dehydrogenase A chain mRNA, mapped to UniProt ENSG00000134333.

Mapped IDENSG00000134333
Review nameL-lactate dehydrogenase A chain mRNA
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

L-lactate dehydrogenase A chain mRNA shows approved-linked disease relevance led by primary hyperoxaluria. 1 more disease program remain visible in the same review block.

Approved-linked Approved
primary hyperoxaluria
1 linked drug · 1 direct · 1 efficacy
Linked drugNEDOSIRAN SODIUM
Approved-linked Approved
primary hyperoxaluria type 1
1 linked drug · 1 direct · 1 efficacy
Linked drugNEDOSIRAN SODIUM
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with primary hyperoxaluria because it currently carries approved-linked support. Linked drugs include NEDOSIRAN SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseprimary hyperoxaluria
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine