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Target Snapshot

CHEMBL4630671 Target Snapshot

Leishmania orientalis · ORGANISM · Leishmania orientalis

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20Compounds
5Assays
1Approved Drugs
40.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leishmania orientalis as ChEMBL target CHEMBL4630671. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leishmania orientalis
ORGANISM · Leishmania orientalis
As of 2026-09-14
ChEMBL target ID
CHEMBL4630671
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leishmania orientalis still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeishmania orientalis
Target TypeORGANISM
OrganismLeishmania orientalis
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeishmania orientalis
UniProt AccessionN/A

Leishmania orientalis

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leishmania orientalis.

Review nameLeishmania orientalis
OrganismLeishmania orientalis
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5040.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL267345 7.64 IC50 23.0 Approved
CHEMBL4638600 7.4 IC50 40.0 Preclinical
CHEMBL4638482 7.19 IC50 65.0 Preclinical
CHEMBL4643116 7.11 IC50 77.0 Preclinical
CHEMBL4646044 7.1 IC50 80.0 Preclinical
CHEMBL584818 7.1 IC50 80.0 Preclinical
CHEMBL4649254 7.09 IC50 81.0 Preclinical
CHEMBL4642489 7.07 IC50 85.0 Preclinical
CHEMBL4634435 7.06 IC50 88.0 Preclinical
CHEMBL4649340 7.01 IC50 98.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
10
6.5
9
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AMPHOTERICIN B
CHEMBL267345
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
12
Tested Compounds
1
Assay Types
Functional — 5 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 5 12 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine