Protein cereblon/Serine/threonine-protein kinase WEE1 · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P30291. Use UniProt P30291 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30291 as the stable identity anchor, then attach disease evidence before program review.
Wee1-like protein kinase
Review this target as Protein cereblon/Serine/threonine-protein kinase WEE1, mapped to UniProt P30291. ChEMBL maps the protein component as Wee1-like protein kinase. Sequence length is 646 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein cereblon/Serine/threonine-protein kinase WEE1 as ChEMBL target CHEMBL4630732, mapped to UniProt P30291. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Protein cereblon/Serine/threonine-protein kinase WEE1 |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P30291 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Wee1-like protein kinase |
| UniProt Accession | P30291 |
| Component Type | Protein |
| Sequence Length | 646 aa |
Wee1-like protein kinase
Review this target as Protein cereblon/Serine/threonine-protein kinase WEE1, mapped to UniProt P30291. ChEMBL maps the protein component as Wee1-like protein kinase. Sequence length is 646 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4638510 | 8.45 | IC50 | 3.58 | Preclinical |
| CHEMBL1976040 | 7.76 | IC50 | 17.28 | Clinical |
| CHEMBL5432090 | 7.25 | IC50 | 56.88 | Preclinical |
| CHEMBL5412009 | 7.12 | IC50 | 75.33 | Preclinical |
| CHEMBL5427326 | 7.11 | IC50 | 78.57 | Preclinical |
| CHEMBL5403604 | 7.1 | IC50 | 79.47 | Preclinical |
| CHEMBL5412194 | 7.06 | IC50 | 86.73 | Preclinical |
| CHEMBL4638510 | 7.0 | EC50 | 100.0 | Preclinical |
| CHEMBL5421561 | 6.86 | IC50 | 138.05 | Preclinical |
| CHEMBL5405576 | 6.84 | IC50 | 142.75 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 53 | 1 | 7.0 |
| protein format | 2 | 19 | 6.7 |