5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P28223. Use UniProt P28223 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28223 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2, mapped to UniProt P28223. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2A. Sequence length is 471 aa.
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This review treats 5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 as ChEMBL target CHEMBL4630758, mapped to UniProt P28223. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P28223 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2A |
| UniProt Accession | P28223 |
| Component Type | Protein |
| Sequence Length | 471 aa |
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2, mapped to UniProt P28223. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2A. Sequence length is 471 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4638006 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL4638006 | 8.27 | IC50 | 5.4 | Preclinical |
| CHEMBL4636980 | 8.19 | Ki | 6.457 | Preclinical |
| CHEMBL489624 | 8.04 | IC50 | 9.12 | Preclinical |
| CHEMBL4636980 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL2206440 | 7.72 | EC50 | 19.0 | Preclinical |
| CHEMBL4646555 | 7.72 | EC50 | 19.0 | Preclinical |
| CHEMBL4632373 | 7.62 | EC50 | 23.99 | Preclinical |
| CHEMBL4646835 | 7.6 | EC50 | 25.0 | Preclinical |
| CHEMBL4643961 | 7.51 | EC50 | 30.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 17 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 9 | 7.0 |