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Target Snapshot

CHEMBL4630759 Target Snapshot

TEL/KDR · CHIMERIC PROTEIN · Homo sapiens

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23Compounds
2Assays
1Approved Drugs
23.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P35968. Use UniProt P35968 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35968 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats TEL/KDR as ChEMBL target CHEMBL4630759, mapped to UniProt P35968. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
TEL/KDR
CHIMERIC PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4630759
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P35968
Vascular endothelial growth factor receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether TEL/KDR is the right protein anchor across sources, using UniProt P35968 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTEL/KDR
Target TypeCHIMERIC PROTEIN
OrganismHomo sapiens
UniProtP35968
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVascular endothelial growth factor receptor 2
UniProt AccessionP35968
Component TypeProtein
Sequence Length1356 aa

Vascular endothelial growth factor receptor 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as TEL/KDR, mapped to UniProt P35968. ChEMBL maps the protein component as Vascular endothelial growth factor receptor 2. Sequence length is 1356 aa.

Mapped IDP35968
Review nameTEL/KDR
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC5023.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3828009 8.05 IC50 9.0 Preclinical
CHEMBL5593851 6.79 IC50 162.0 Preclinical
CHEMBL5591286 6.7 IC50 198.0 Preclinical
CHEMBL5591378 6.5 IC50 314.0 Preclinical
CHEMBL5594702 6.49 IC50 323.0 Preclinical
CHEMBL5595996 6.25 IC50 560.0 Preclinical
CHEMBL5590027 6.23 IC50 586.0 Preclinical
CHEMBL3545376 6.2 IC50 627.0 Approved
CHEMBL5590821 6.2 IC50 637.0 Preclinical
CHEMBL5594925 6.17 IC50 679.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
5
5.5
10
6.0
3
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ERDAFITINIB
CHEMBL3545376
Approved 2019
Properties Compare Identifier
Assay Landscape

Assay Landscape

2
Total Assays
20
Tested Compounds
1
Assay Types
Binding — 2 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 20 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine