Sodium channel protein type 1 subunit alpha/beta-1/beta-2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P35498. Use UniProt P35498 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35498 as the stable identity anchor, then attach disease evidence before program review.
Sodium channel protein type 1 subunit alpha
Review this target as Sodium channel protein type 1 subunit alpha/beta-1/beta-2, mapped to UniProt P35498. ChEMBL maps the protein component as Sodium channel protein type 1 subunit alpha. Sequence length is 2009 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium channel protein type 1 subunit alpha/beta-1/beta-2 as ChEMBL target CHEMBL4630760, mapped to UniProt P35498. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sodium channel protein type 1 subunit alpha/beta-1/beta-2 is the right protein anchor across sources, using UniProt P35498 as the stable mapping.
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| Preferred Name | Sodium channel protein type 1 subunit alpha/beta-1/beta-2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P35498 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium channel protein type 1 subunit alpha |
| UniProt Accession | P35498 |
| Component Type | Protein |
| Sequence Length | 2009 aa |
Sodium channel protein type 1 subunit alpha
Review this target as Sodium channel protein type 1 subunit alpha/beta-1/beta-2, mapped to UniProt P35498. ChEMBL maps the protein component as Sodium channel protein type 1 subunit alpha. Sequence length is 2009 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3657855 | 7.97 | IC50 | 10.6 | Preclinical |
| CHEMBL5094715 | 6.7 | IC50 | 202.0 | Preclinical |
| CHEMBL5284082 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL5286829 | 5.32 | IC50 | 4800.0 | Preclinical |
| CHEMBL5286433 | 5.18 | IC50 | 6600.0 | Preclinical |
| CHEMBL5267728 | 5.0 | IC50 | 9900.0 | Preclinical |
| CHEMBL5280425 | 4.92 | IC50 | 12000.0 | Preclinical |
| CHEMBL4633573 | 4.89 | IC50 | 13000.0 | Preclinical |
| CHEMBL4642940 | 4.85 | IC50 | 14000.0 | Preclinical |
| CHEMBL4639987 | 4.8 | IC50 | 16000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 7 | 4.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 14 | 5.1 |