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CHEMBL4630766 Target Snapshot

Sodium channel protein type 9 subunit alpha/beta-1/beta-2 · PROTEIN COMPLEX · Mus musculus

43Compounds
5Assays
0Approved Drugs
45.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q62205. Use UniProt Q62205 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q62205 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Sodium channel protein type 9 subunit alpha

Sodium channel protein type 9 subunit alpha

Review this target as Sodium channel protein type 9 subunit alpha/beta-1/beta-2, mapped to UniProt Q62205. ChEMBL maps the protein component as Sodium channel protein type 9 subunit alpha. Sequence length is 1984 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q62205 Protein 1984 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium channel protein type 9 subunit alpha/beta-1/beta-2 as ChEMBL target CHEMBL4630766, mapped to UniProt Q62205. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium channel protein type 9 subunit alpha/beta-1/beta-2
PROTEIN COMPLEX · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4630766
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q62205
Sodium channel protein type 9 subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium channel protein type 9 subunit alpha/beta-1/beta-2 is the right protein anchor across sources, using UniProt Q62205 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium channel protein type 9 subunit alpha
UniProt AccessionQ62205
Component TypeProtein
Sequence Length1984 aa

Sodium channel protein type 9 subunit alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sodium channel protein type 9 subunit alpha/beta-1/beta-2, mapped to UniProt Q62205. ChEMBL maps the protein component as Sodium channel protein type 9 subunit alpha. Sequence length is 1984 aa.

Mapped IDQ62205
Review nameSodium channel protein type 9 subunit alpha/beta-1/beta-2
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC5045.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2325622 9.26 IC50 0.55 Preclinical
CHEMBL2325014 8.31 IC50 4.9 Clinical
CHEMBL4639987 7.82 IC50 15.0 Preclinical
CHEMBL5284082 7.82 IC50 15.0 Preclinical
CHEMBL5276801 7.8 IC50 16.0 Preclinical
CHEMBL4642571 7.77 IC50 17.0 Preclinical
CHEMBL4633566 7.58 IC50 26.5 Clinical
CHEMBL4637488 7.55 IC50 28.0 Preclinical
CHEMBL4637909 7.55 IC50 28.0 Preclinical
CHEMBL4642940 7.39 IC50 41.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
11
5.5
6
6.0
1
6.5
7
7.0
7
7.5
1
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
35
Tested Compounds
1
Assay Types
Binding — 5 assays, 35 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 35 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine