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Target Snapshot

CHEMBL4630776 Target Snapshot

SW620/AD300 · CELL-LINE · Homo sapiens

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173Compounds
36Assays
3Approved Drugs
64.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SW620/AD300 as ChEMBL target CHEMBL4630776. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SW620/AD300
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4630776
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SW620/AD300 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSW620/AD300
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSW620/AD300
UniProt AccessionN/A

SW620/AD300

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SW620/AD300.

Review nameSW620/AD300
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5064.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4205613 7.57 IC50 27.0 Preclinical
CHEMBL4215928 7.52 IC50 30.0 Preclinical
CHEMBL4202712 7.3 IC50 50.0 Preclinical
CHEMBL4209981 7.22 IC50 60.0 Preclinical
CHEMBL4204700 7.0 IC50 100.0 Preclinical
CHEMBL5410959 6.87 IC50 134.0 Preclinical
CHEMBL5424878 6.69 IC50 205.0 Preclinical
CHEMBL247473 6.65 IC50 223.0 Preclinical
CHEMBL5422284 6.42 IC50 379.0 Preclinical
CHEMBL5429889 6.3 IC50 498.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
2
5.5
7
6.0
3
6.5
3
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

36
Total Assays
20
Tested Compounds
2
Assay Types
Functional — 30 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 26 20 6.2
organism-based format 4 0 —
ADME — 6 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 3 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine