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Target Snapshot

CHEMBL4631 Target Snapshot

Endothelin receptor type B · SINGLE PROTEIN · Rattus norvegicus

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391Compounds
47Assays
2Approved Drugs
371.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P21451. Use UniProt P21451 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P21451 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Endothelin receptor type B as ChEMBL target CHEMBL4631, mapped to UniProt P21451. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Endothelin receptor type B
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL4631
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P21451
Endothelin receptor type B
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Endothelin receptor type B is the right protein anchor across sources, using UniProt P21451 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameEndothelin receptor type B
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP21451
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEndothelin receptor type B
UniProt AccessionP21451
Component TypeProtein
Sequence Length442 aa

Endothelin receptor type B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Endothelin receptor type B, mapped to UniProt P21451. Sequence length is 442 aa.

Mapped IDP21451
Review nameEndothelin receptor type B
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
3
Phase II
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC50257.0
KI88.0
EC507.0
KD19.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL437472 11.0 Ki 0.01 Clinical
CHEMBL4524099 10.92 Ki 0.012 Preclinical
CHEMBL4524100 10.8 Ki 0.016 Preclinical
CHEMBL1790180 10.68 Ki 0.021 Preclinical
CHEMBL437472 8.8 IC50 1.6 Clinical
CHEMBL313153 8.77 IC50 1.7 Preclinical
CHEMBL87070 8.59 IC50 2.6 Preclinical
CHEMBL313044 8.49 IC50 3.2 Preclinical
CHEMBL314973 8.49 IC50 3.2 Preclinical
CHEMBL315280 8.48 IC50 3.3 Preclinical
Distribution

pChEMBL Value Distribution

70
5.0
49
5.5
32
6.0
29
6.5
33
7.0
17
7.5
14
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

BOSENTAN
CHEMBL957
Approved 2001
Properties Compare Identifier
Assay Landscape

Assay Landscape

47
Total Assays
248
Tested Compounds
2
Assay Types
Binding — 36 assays, 248 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 14 161 6.0
single protein format 11 18 5.7
cell membrane format 9 26 6.2
assay format 2 43 6.4
Functional — 11 assays, 39 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 2 6.5
organism-based format 3 0 —
cell-based format 2 14 6.1
tissue-based format 2 23 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine