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Target Snapshot

CHEMBL4638 Target Snapshot

Endochitinase B1 · SINGLE PROTEIN · Aspergillus fumigatus

7Compounds
4Assays
0Approved Drugs
7.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt Q873X9. Use UniProt Q873X9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q873X9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Endochitinase B1 as ChEMBL target CHEMBL4638, mapped to UniProt Q873X9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Endochitinase B1
SINGLE PROTEIN · Aspergillus fumigatus
As of 2026-09-15
ChEMBL target ID
CHEMBL4638
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
Q873X9
Endochitinase B1
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Endochitinase B1 is the right protein anchor across sources, using UniProt Q873X9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEndochitinase B1
UniProt AccessionQ873X9
Component TypeProtein
Sequence Length433 aa

Endochitinase B1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Endochitinase B1, mapped to UniProt Q873X9. Sequence length is 433 aa.

Mapped IDQ873X9
Review nameEndochitinase B1
OrganismAspergillus fumigatus
Assay Mix

Activity Type Distribution

IC506.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL197199 7.77 Ki 17.0 Preclinical
CHEMBL4756641 7.57 IC50 27.0 Preclinical
CHEMBL1738791 6.7 IC50 200.0 Preclinical
CHEMBL1232048 5.32 IC50 4800.0 Preclinical
CHEMBL2058174 5.24 IC50 5700.0 Preclinical
CHEMBL2058173 5.05 IC50 9000.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
0
6.0
1
6.5
0
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
7
Tested Compounds
1
Assay Types
Binding — 4 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 6 6.0
single protein format 2 1 7.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine