Voltage-dependent T-type calcium channel subunit alpha-1G · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O43497. Use UniProt O43497 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O43497 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent T-type calcium channel subunit alpha-1G
Review this target as Voltage-dependent T-type calcium channel subunit alpha-1G, mapped to UniProt O43497. Sequence length is 2377 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-dependent T-type calcium channel subunit alpha-1G as ChEMBL target CHEMBL4641, mapped to UniProt O43497. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-dependent T-type calcium channel subunit alpha-1G |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O43497 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent T-type calcium channel subunit alpha-1G |
| UniProt Accession | O43497 |
| Component Type | Protein |
| Sequence Length | 2377 aa |
Voltage-dependent T-type calcium channel subunit alpha-1G
Review this target as Voltage-dependent T-type calcium channel subunit alpha-1G, mapped to UniProt O43497. Sequence length is 2377 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4206509 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4204077 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL4207291 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL4214862 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL1684950 | 8.92 | IC50 | 1.2 | Clinical |
| CHEMBL4203101 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL4207031 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL4211105 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL4205005 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL4212039 | 8.72 | IC50 | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 59 | 459 | 6.5 |
| single protein format | 12 | 13 | 6.3 |
| assay format | 5 | 42 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 41 | 6.0 |
| assay format | 2 | 6 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 6.1 |
| cell-based format | 1 | 36 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |