Melanocortin receptor 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Melanocortin receptor 3 shows clinical signal disease relevance led by Acute kidney injury. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P41968. Start with Acute kidney injury, then reuse UniProt P41968 as the stable protein anchor across project notes and exports.
Start with Acute kidney injury, then reuse UniProt P41968 as the stable protein anchor across project notes and exports.
Melanocortin receptor 3 shows clinical signal disease relevance led by Acute kidney injury. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Acute kidney injury because it currently carries clinical signal support. Linked drugs include MODIMELANOTIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMelanocortin receptor 3
Review this target as Melanocortin receptor 3, mapped to UniProt P41968. Sequence length is 323 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melanocortin receptor 3 as ChEMBL target CHEMBL4644, mapped to UniProt P41968. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Melanocortin receptor 3 is the right protein anchor across sources, using UniProt P41968 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Acute kidney injury is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Melanocortin receptor 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P41968 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melanocortin receptor 3 |
| UniProt Accession | P41968 |
| Component Type | Protein |
| Sequence Length | 323 aa |
Melanocortin receptor 3
Review this target as Melanocortin receptor 3, mapped to UniProt P41968. Sequence length is 323 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Melanocortin receptor 3 shows clinical signal disease relevance led by Acute kidney injury. 1 more disease program remain visible in the same review block.
Start review with Acute kidney injury because it currently carries clinical signal support. Linked drugs include MODIMELANOTIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4777048 | 10.66 | Ki | 0.02188 | Preclinical |
| CHEMBL253364 | 10.6 | Kd | 0.02512 | Preclinical |
| CHEMBL4794121 | 10.51 | Ki | 0.0309 | Preclinical |
| CHEMBL4798971 | 10.49 | Ki | 0.032 | Preclinical |
| CHEMBL430239 | 10.21 | EC50 | 0.06166 | Preclinical |
| CHEMBL413212 | 10.2 | EC50 | 0.063 | Preclinical |
| CHEMBL5185775 | 9.98 | EC50 | 0.1047 | Preclinical |
| CHEMBL5185945 | 9.97 | EC50 | 0.1072 | Preclinical |
| CHEMBL414718 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL3422426 | 9.89 | Ki | 0.1288 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 78 | 597 | 6.2 |
| single protein format | 69 | 232 | 6.4 |
| cell membrane format | 6 | 78 | 7.2 |
| assay format | 1 | 4 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 98 | 379 | 7.2 |
| assay format | 39 | 114 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 12 | 7.6 |