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Target Snapshot

CHEMBL4649922 Target Snapshot

DNA · NUCLEIC-ACID

Back to Search Search this target Browse approvals Evidence Card
216Compounds
144Assays
1Approved Drugs
57.0Activities
Free Research Context

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Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DNA as ChEMBL target CHEMBL4649922. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DNA
NUCLEIC-ACID
As of 2026-09-14
ChEMBL target ID
CHEMBL4649922
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DNA still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameDNA
Target TypeNUCLEIC-ACID
OrganismNone
ChEMBL ↗ NCBI Nucleotide ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDNA
UniProt AccessionN/A

DNA

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as DNA.

Review nameDNA
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5033.0
KD24.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5563694 6.52 Kd 300.0 Preclinical
CHEMBL5542132 5.73 Kd 1860.0 Preclinical
CHEMBL5562375 5.7 Kd 2000.0 Preclinical
CHEMBL4859606 5.53 Kd 2970.0 Preclinical
CHEMBL5438257 5.28 Kd 5300.0 Preclinical
CHEMBL5423999 5.27 IC50 5400.0 Preclinical
CHEMBL5572579 4.97 Kd 10800.0 Preclinical
CHEMBL5562616 4.89 Kd 13000.0 Preclinical
CHEMBL5584045 4.72 Kd 18900.0 Preclinical
CHEMBL4640631 4.7 Kd 20000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
3
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

145
Total Assays
15
Tested Compounds
4
Assay Types
Binding — 134 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
nucleic acid format 134 15 5.0
Functional — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 8 0 —
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
nucleic acid format 2 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine