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Target Snapshot

CHEMBL4649925 Target Snapshot

Supercoiled DNA · NUCLEIC-ACID

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50Compounds
45Assays
0Approved Drugs
12.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Supercoiled DNA as ChEMBL target CHEMBL4649925. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Supercoiled DNA
NUCLEIC-ACID
As of 2026-09-14
ChEMBL target ID
CHEMBL4649925
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Supercoiled DNA still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSupercoiled DNA
Target TypeNUCLEIC-ACID
OrganismNone
ChEMBL ↗ NCBI Nucleotide ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSupercoiled DNA
UniProt AccessionN/A

Supercoiled DNA

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Supercoiled DNA.

Review nameSupercoiled DNA
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

EC5011.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5557704 7.76 EC50 17.3 Preclinical
CHEMBL5557402 7.48 EC50 33.2 Preclinical
CHEMBL4636420 7.41 EC50 38.9 Preclinical
CHEMBL5557975 7.12 EC50 75.5 Preclinical
CHEMBL5560250 7.1 EC50 79.0 Preclinical
CHEMBL4466320 7.08 EC50 83.3 Preclinical
CHEMBL5557688 6.61 EC50 248.5 Preclinical
CHEMBL4472466 6.58 EC50 260.6 Preclinical
CHEMBL5559818 6.23 EC50 583.2 Preclinical
CHEMBL5555325 6.12 EC50 759.6 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
2
6.0
2
6.5
5
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

45
Total Assays
11
Tested Compounds
1
Assay Types
Binding — 45 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
nucleic acid format 45 11 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine