Confirm a stable target identifier before relying on this context across project surfaces.
CHEMBL4651286 Target Snapshot
Aorta · TISSUE · Oryctolagus cuniculus
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As of 2026-09-13Confirm a stable target identifier before relying on this context across project surfaces.
Aorta
Review this target as Aorta.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Aorta as ChEMBL target CHEMBL4651286. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Aorta |
| Target Type | TISSUE |
| Organism | Oryctolagus cuniculus |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
How to read this target
Review this target as Aorta.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5425229 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL510226 | 7.46 | EC50 | 34.67 | Preclinical |
| CHEMBL4650322 | 7.41 | IC50 | 39.0 | Clinical |
| CHEMBL512979 | 7.4 | EC50 | 39.81 | Preclinical |
| CHEMBL513873 | 7.32 | EC50 | 47.86 | Preclinical |
| CHEMBL492795 | 7.28 | EC50 | 52.48 | Preclinical |
| CHEMBL467592 | 7.28 | EC50 | 52.48 | Preclinical |
| CHEMBL467593 | 7.28 | EC50 | 52.48 | Preclinical |
| CHEMBL192 | 7.25 | EC50 | 56.23 | Approved |
| CHEMBL449906 | 7.22 | EC50 | 60.26 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Functional — 12 assays, 30 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 11 | 29 | 6.8 |
| assay format | 1 | 1 | 6.2 |