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Target Snapshot

CHEMBL4651286 Target Snapshot

Aorta · TISSUE · Oryctolagus cuniculus

34Compounds
12Assays
3Approved Drugs
51.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Aorta as ChEMBL target CHEMBL4651286. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Aorta
TISSUE · Oryctolagus cuniculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4651286
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Aorta still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAorta
UniProt AccessionN/A

Aorta

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Aorta.

Review nameAorta
OrganismOryctolagus cuniculus
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC508.0
EC5043.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5425229 7.57 IC50 27.0 Preclinical
CHEMBL510226 7.46 EC50 34.67 Preclinical
CHEMBL4650322 7.41 IC50 39.0 Clinical
CHEMBL512979 7.4 EC50 39.81 Preclinical
CHEMBL513873 7.32 EC50 47.86 Preclinical
CHEMBL492795 7.28 EC50 52.48 Preclinical
CHEMBL467592 7.28 EC50 52.48 Preclinical
CHEMBL467593 7.28 EC50 52.48 Preclinical
CHEMBL192 7.25 EC50 56.23 Approved
CHEMBL449906 7.22 EC50 60.26 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
8
6.0
20
6.5
20
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VERICIGUAT
CHEMBL4066936
Approved 2021
RIOCIGUAT
CHEMBL2107834
Approved 2013
SILDENAFIL
CHEMBL192
Approved 1998
Assay Landscape

Assay Landscape

12
Total Assays
30
Tested Compounds
1
Assay Types
Functional — 12 assays, 30 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 11 29 6.8
assay format 1 1 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine