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Target Snapshot

CHEMBL4651302 Target Snapshot

L-arginine · SMALL MOLECULE · Homo sapiens

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

L-arginine shows approved-linked disease relevance led by Argininemia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Use Argininemia as the disease frame, then confirm a stable protein accession before cross-source reuse.

Review focus
Disease frame ready

Use Argininemia as the disease frame, then confirm a stable protein accession before cross-source reuse.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
Argininemia

L-arginine shows approved-linked disease relevance led by Argininemia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with Argininemia because it currently carries approved-linked support. Linked drugs include PEGZILARGINASE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats L-arginine as ChEMBL target CHEMBL4651302. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L-arginine
SMALL MOLECULE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4651302
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether L-arginine still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Argininemia is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelL-arginine
UniProt AccessionN/A

L-arginine

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as L-arginine.

Review nameL-arginine
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

L-arginine shows approved-linked disease relevance led by Argininemia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Argininemia
1 linked drug · 1 direct · 1 efficacy
Linked drugPEGZILARGINASE
Late clinical Phase III
hepatocellular carcinoma
1 linked drug · 1 direct · 1 efficacy
Linked drugPEGARGIMINASE
Late clinical Phase III
soft tissue sarcoma
1 linked drug · 1 direct · 1 efficacy
Linked drugPEGARGIMINASE
Clinical signal Phase II
acute myeloid leukemia
2 linked drugs · 2 direct · 2 efficacy
Linked drugPEGARGIMINASE
Linked drugPEGZILARGINASE
Clinical signal Phase II
small cell lung carcinoma
2 linked drugs · 2 direct · 2 efficacy
Linked drugPEGARGIMINASE
Linked drugPEGZILARGINASE
Clinical signal Phase II
cutaneous melanoma
1 linked drug · 1 direct · 1 efficacy
Linked drugPEGARGIMINASE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with Argininemia because it currently carries approved-linked support. Linked drugs include PEGZILARGINASE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseArgininemia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine