Histidine--tRNA ligase · SINGLE PROTEIN · Trypanosoma cruzi (strain CL Brener)
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As of 2026-09-14Protein identity stays anchored to UniProt Q4DA54. Use UniProt Q4DA54 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q4DA54 as the stable identity anchor, then attach disease evidence before program review.
histidine--tRNA ligase
Review this target as Histidine--tRNA ligase, mapped to UniProt Q4DA54. ChEMBL maps the protein component as histidine--tRNA ligase. Sequence length is 478 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histidine--tRNA ligase as ChEMBL target CHEMBL4662925, mapped to UniProt Q4DA54. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histidine--tRNA ligase |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi (strain CL Brener) |
| UniProt | Q4DA54 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | histidine--tRNA ligase |
| UniProt Accession | Q4DA54 |
| Component Type | Protein |
| Sequence Length | 478 aa |
histidine--tRNA ligase
Review this target as Histidine--tRNA ligase, mapped to UniProt Q4DA54. ChEMBL maps the protein component as histidine--tRNA ligase. Sequence length is 478 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3443461 | 5.87 | IC50 | 1342.62 | Preclinical |
| CHEMBL3443478 | 5.65 | IC50 | 2235.15 | Preclinical |
| CHEMBL3443502 | 5.62 | IC50 | 2415.11 | Preclinical |
| CHEMBL3457942 | 5.62 | IC50 | 2370.43 | Preclinical |
| CHEMBL3489710 | 5.6 | IC50 | 2524.55 | Preclinical |
| CHEMBL3461744 | 5.48 | IC50 | 3340.82 | Preclinical |
| CHEMBL3443506 | 5.46 | IC50 | 3501.61 | Preclinical |
| CHEMBL3461750 | 5.46 | IC50 | 3424.32 | Preclinical |
| CHEMBL3444410 | 5.42 | IC50 | 3843.67 | Preclinical |
| CHEMBL3443504 | 5.41 | IC50 | 3928.73 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 78 | 4.8 |