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Target Snapshot

CHEMBL4662933 Target Snapshot

Lanosterol 14-alpha demethylase · SINGLE PROTEIN · Fungi

0Compounds
0Assays
0Approved Drugs
0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Lanosterol 14-alpha demethylase shows approved-linked disease relevance led by vulvovaginal candidiasis. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P10613. Start with vulvovaginal candidiasis, then reuse UniProt P10613 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with vulvovaginal candidiasis, then reuse UniProt P10613 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
vulvovaginal candidiasis

Lanosterol 14-alpha demethylase shows approved-linked disease relevance led by vulvovaginal candidiasis. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with vulvovaginal candidiasis because it currently carries approved-linked support. Linked drugs include OTESECONAZOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lanosterol 14-alpha demethylase as ChEMBL target CHEMBL4662933, mapped to UniProt P10613. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lanosterol 14-alpha demethylase
SINGLE PROTEIN · Fungi
As of 2026-09-13
ChEMBL target ID
CHEMBL4662933
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P10613
Lanosterol 14-alpha demethylase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lanosterol 14-alpha demethylase is the right protein anchor across sources, using UniProt P10613 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why vulvovaginal candidiasis is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLanosterol 14-alpha demethylase
UniProt AccessionP10613
Component TypeProtein
Sequence Length528 aa

Lanosterol 14-alpha demethylase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lanosterol 14-alpha demethylase, mapped to UniProt P10613. Sequence length is 528 aa.

Mapped IDP10613
Review nameLanosterol 14-alpha demethylase
OrganismFungi
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Lanosterol 14-alpha demethylase shows approved-linked disease relevance led by vulvovaginal candidiasis. 4 more disease programs remain visible in the same review block.

Approved-linked Approved
vulvovaginal candidiasis
1 linked drug · 1 direct · 1 efficacy
Linked drugOTESECONAZOLE
Late clinical Phase III
tinea unguium
3 linked drugs · 3 direct · 3 efficacy
Linked drugALBACONAZOLE
Linked drugBIFONAZOLE
Linked drugOTESECONAZOLE
Clinical signal Phase II
tinea pedis
3 linked drugs · 3 direct · 3 efficacy
Linked drugALBACONAZOLE
Linked drugBIFONAZOLE
Linked drugOTESECONAZOLE
Clinical signal Phase II
vulvovaginitis
1 linked drug · 1 direct · 1 efficacy
Linked drugALBACONAZOLE
Clinical signal Phase I
fungal infectious disease
1 linked drug · 1 direct · 1 efficacy
Linked drugOTESECONAZOLE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with vulvovaginal candidiasis because it currently carries approved-linked support. Linked drugs include OTESECONAZOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasevulvovaginal candidiasis
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine