Mitogen-activated protein kinase 12 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P53778. Use UniProt P53778 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P53778 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 12
Review this target as Mitogen-activated protein kinase 12, mapped to UniProt P53778. Sequence length is 367 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase 12 as ChEMBL target CHEMBL4674, mapped to UniProt P53778. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase 12 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P53778 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 12 |
| UniProt Accession | P53778 |
| Component Type | Protein |
| Sequence Length | 367 aa |
Mitogen-activated protein kinase 12
Review this target as Mitogen-activated protein kinase 12, mapped to UniProt P53778. Sequence length is 367 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL103667 | 8.54 | Kd | 2.9 | Clinical |
| CHEMBL5808926 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL3695569 | 8.3 | Kd | 5.0 | Preclinical |
| CHEMBL6052957 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL5197888 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5988627 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5822857 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL5831636 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL6001529 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5184542 | 7.8 | IC50 | 16.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 346 | 136 | 6.6 |
| assay format | 59 | 6 | 6.7 |
| cell-based format | 14 | 2 | 6.0 |
| subcellular format | 8 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 108 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |