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Target Snapshot

CHEMBL4676 Target Snapshot

Voltage-dependent calcium channel subunit alpha-2/delta-1 · SINGLE PROTEIN · Mus musculus

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55Compounds
3Assays
1Approved Drugs
100.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O08532. Use UniProt O08532 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O08532 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Voltage-dependent calcium channel subunit alpha-2/delta-1 as ChEMBL target CHEMBL4676, mapped to UniProt O08532. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Voltage-dependent calcium channel subunit alpha-2/delta-1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4676
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O08532
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Voltage-dependent calcium channel subunit alpha-2/delta-1 is the right protein anchor across sources, using UniProt O08532 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameVoltage-dependent calcium channel subunit alpha-2/delta-1
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtO08532
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVoltage-dependent calcium channel subunit alpha-2/delta-1
UniProt AccessionO08532
Component TypeProtein
Sequence Length1103 aa

Voltage-dependent calcium channel subunit alpha-2/delta-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Voltage-dependent calcium channel subunit alpha-2/delta-1, mapped to UniProt O08532. Sequence length is 1103 aa.

Mapped IDO08532
Review nameVoltage-dependent calcium channel subunit alpha-2/delta-1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

KI100.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL382682 8.44 Ki 3.631 Preclinical
CHEMBL377079 8.37 Ki 4.266 Preclinical
CHEMBL203746 8.35 Ki 4.5 Preclinical
CHEMBL413572 8.28 Ki 5.3 Preclinical
CHEMBL203743 8.12 Ki 7.586 Preclinical
CHEMBL381281 7.76 Ki 17.38 Preclinical
CHEMBL204818 7.73 Ki 18.62 Preclinical
CHEMBL204611 7.72 Ki 19.0 Preclinical
CHEMBL204646 7.7 Ki 20.0 Preclinical
CHEMBL205126 7.68 Ki 20.89 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
5
5.5
12
6.0
21
6.5
21
7.0
18
7.5
10
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GABAPENTIN
CHEMBL940
Approved 1993
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
49
Tested Compounds
2
Assay Types
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —
organism-based format 1 0 —
Binding — 1 assays, 49 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 49 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine