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Target Snapshot

CHEMBL4680 Target Snapshot

3-dehydroquinate dehydratase · SINGLE PROTEIN · Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)

34Compounds
7Assays
1Approved Drugs
34.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q48255. Use UniProt Q48255 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q48255 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 3-dehydroquinate dehydratase as ChEMBL target CHEMBL4680, mapped to UniProt Q48255. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
3-dehydroquinate dehydratase
SINGLE PROTEIN · Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
As of 2026-09-13
ChEMBL target ID
CHEMBL4680
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q48255
3-dehydroquinate dehydratase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 3-dehydroquinate dehydratase is the right protein anchor across sources, using UniProt Q48255 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label3-dehydroquinate dehydratase
UniProt AccessionQ48255
Component TypeProtein
Sequence Length167 aa

3-dehydroquinate dehydratase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 3-dehydroquinate dehydratase, mapped to UniProt Q48255. Sequence length is 167 aa.

Mapped IDQ48255
Review name3-dehydroquinate dehydratase
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KI31.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1823563 7.3 Ki 50.0 Preclinical
CHEMBL1823562 7.01 Ki 97.0 Preclinical
CHEMBL1823571 7.0 Ki 100.0 Preclinical
CHEMBL567564 6.89 Ki 130.0 Preclinical
CHEMBL567563 6.88 Ki 132.0 Preclinical
CHEMBL1823565 6.85 Ki 140.0 Preclinical
CHEMBL3221802 6.8 Ki 157.0 Preclinical
CHEMBL576247 6.78 Ki 166.0 Preclinical
CHEMBL1823560 6.69 Ki 205.0 Preclinical
CHEMBL1823559 6.65 Ki 225.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
3
5.5
5
6.0
11
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
34
Tested Compounds
1
Assay Types
Binding — 7 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 20 6.2
assay format 1 6 4.6
cell-based format 1 8 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine