Use UniProt Q48255 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4680 Target Snapshot
3-dehydroquinate dehydratase · SINGLE PROTEIN · Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
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As of 2026-09-13Protein identity stays anchored to UniProt Q48255. Use UniProt Q48255 as the stable identity anchor, then attach disease evidence before program review.
3-dehydroquinate dehydratase
Review this target as 3-dehydroquinate dehydratase, mapped to UniProt Q48255. Sequence length is 167 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats 3-dehydroquinate dehydratase as ChEMBL target CHEMBL4680, mapped to UniProt Q48255. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 3-dehydroquinate dehydratase |
| Target Type | SINGLE PROTEIN |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
| UniProt | Q48255 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3-dehydroquinate dehydratase |
| UniProt Accession | Q48255 |
| Component Type | Protein |
| Sequence Length | 167 aa |
3-dehydroquinate dehydratase
How to read this target
Review this target as 3-dehydroquinate dehydratase, mapped to UniProt Q48255. Sequence length is 167 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1823563 | 7.3 | Ki | 50.0 | Preclinical |
| CHEMBL1823562 | 7.01 | Ki | 97.0 | Preclinical |
| CHEMBL1823571 | 7.0 | Ki | 100.0 | Preclinical |
| CHEMBL567564 | 6.89 | Ki | 130.0 | Preclinical |
| CHEMBL567563 | 6.88 | Ki | 132.0 | Preclinical |
| CHEMBL1823565 | 6.85 | Ki | 140.0 | Preclinical |
| CHEMBL3221802 | 6.8 | Ki | 157.0 | Preclinical |
| CHEMBL576247 | 6.78 | Ki | 166.0 | Preclinical |
| CHEMBL1823560 | 6.69 | Ki | 205.0 | Preclinical |
| CHEMBL1823559 | 6.65 | Ki | 225.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 7 assays, 34 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 20 | 6.2 |
| assay format | 1 | 6 | 4.6 |
| cell-based format | 1 | 8 | 6.2 |