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Target Snapshot

CHEMBL4691 Target Snapshot

Proteinase-activated receptor 4 · SINGLE PROTEIN · Homo sapiens

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1,335Compounds
81Assays
0Approved Drugs
2,841.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Proteinase-activated receptor 4 shows clinical signal disease relevance led by coronary artery disease. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q96RI0. Start with coronary artery disease, then reuse UniProt Q96RI0 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with coronary artery disease, then reuse UniProt Q96RI0 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
coronary artery disease

Proteinase-activated receptor 4 shows clinical signal disease relevance led by coronary artery disease. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with coronary artery disease because it currently carries clinical signal support. Linked drugs include BMS-986141. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Proteinase-activated receptor 4 as ChEMBL target CHEMBL4691, mapped to UniProt Q96RI0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Proteinase-activated receptor 4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4691
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q96RI0
Proteinase-activated receptor 4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Proteinase-activated receptor 4 is the right protein anchor across sources, using UniProt Q96RI0 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why coronary artery disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProteinase-activated receptor 4
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ96RI0
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProteinase-activated receptor 4
UniProt AccessionQ96RI0
Component TypeProtein
Sequence Length385 aa

Proteinase-activated receptor 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Proteinase-activated receptor 4, mapped to UniProt Q96RI0. Sequence length is 385 aa.

Mapped IDQ96RI0
Review nameProteinase-activated receptor 4
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Proteinase-activated receptor 4 shows clinical signal disease relevance led by coronary artery disease. 3 more disease programs remain visible in the same review block.

Clinical signal Phase II
coronary artery disease
1 linked drug · 1 direct · 1 efficacy
Linked drugBMS-986141
Clinical signal Phase II
thrombotic disease
1 linked drug · 1 direct · 1 efficacy
Linked drugBMS-986141
Clinical signal Phase I
Ischemic stroke
1 linked drug · 1 direct · 1 efficacy
Linked drugBMS-986141
Clinical signal Phase I
liver disease
1 linked drug · 1 direct · 1 efficacy
Linked drugBMS-986141
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with coronary artery disease because it currently carries clinical signal support. Linked drugs include BMS-986141. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecoronary artery disease
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

3
Phase II
Assay Mix

Activity Type Distribution

IC501,662.0
EC501,173.0
KD6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3715848 10.64 IC50 0.0229 Preclinical
CHEMBL3716726 10.15 Kd 0.07 Preclinical
CHEMBL3716552 10.07 Kd 0.086 Clinical
CHEMBL3715479 9.74 EC50 0.18 Preclinical
CHEMBL3716230 9.7 IC50 0.2 Preclinical
CHEMBL3718225 9.68 EC50 0.21 Preclinical
CHEMBL6056014 9.68 EC50 0.21 Preclinical
CHEMBL3715013 9.64 IC50 0.23 Preclinical
CHEMBL3716420 9.64 EC50 0.23 Preclinical
CHEMBL3716902 9.64 IC50 0.23 Preclinical
Distribution

pChEMBL Value Distribution

45
5.0
125
5.5
210
6.0
175
6.5
191
7.0
234
7.5
382
8.0
592
8.5
674
9.0
79
9.5
pChEMBL
Assay Landscape

Assay Landscape

81
Total Assays
1,463
Tested Compounds
2
Assay Types
Binding — 54 assays, 1,463 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 30 374 8.1
single protein format 11 6 8.9
cell-based format 10 1,055 8.2
cell-free format 2 27 6.1
tissue-based format 1 1 8.0
Functional — 27 assays, 1,027 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 895 8.2
cell-free format 10 129 7.1
assay format 7 3 8.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine