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Target Snapshot

CHEMBL4695 Target Snapshot

Fructose-bisphosphate aldolase A · SINGLE PROTEIN · Oryctolagus cuniculus

242Compounds
11Assays
0Approved Drugs
26.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P00883. Use UniProt P00883 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00883 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fructose-bisphosphate aldolase A as ChEMBL target CHEMBL4695, mapped to UniProt P00883. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fructose-bisphosphate aldolase A
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4695
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P00883
Fructose-bisphosphate aldolase A
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fructose-bisphosphate aldolase A is the right protein anchor across sources, using UniProt P00883 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFructose-bisphosphate aldolase A
UniProt AccessionP00883
Component TypeProtein
Sequence Length364 aa

Fructose-bisphosphate aldolase A

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Fructose-bisphosphate aldolase A, mapped to UniProt P00883. Sequence length is 364 aa.

Mapped IDP00883
Review nameFructose-bisphosphate aldolase A
OrganismOryctolagus cuniculus
Assay Mix

Activity Type Distribution

IC5013.0
KI13.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL371668 6.0 Ki 1000.0 Preclinical
CHEMBL2017785 5.12 IC50 7500.0 Preclinical
CHEMBL258208 5.1 IC50 8000.0 Preclinical
CHEMBL1235112 4.89 IC50 13000.0 Preclinical
CHEMBL1235112 4.82 Ki 15000.0 Preclinical
CHEMBL2017790 4.77 IC50 17000.0 Preclinical
CHEMBL2017788 4.68 IC50 21000.0 Preclinical
CHEMBL2017786 4.19 IC50 64000.0 Preclinical
CHEMBL1278173 4.17 Ki 67000.0 Preclinical
CHEMBL1082691 4.06 IC50 87000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

11
Total Assays
20
Tested Compounds
2
Assay Types
Binding — 10 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 15 4.8
tissue-based format 2 0
assay format 1 5 4.5
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine