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Target Snapshot

CHEMBL4696 Target Snapshot

Glycogen phosphorylase, muscle form · SINGLE PROTEIN · Oryctolagus cuniculus

836Compounds
120Assays
1Approved Drugs
1,058.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P00489. Use UniProt P00489 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00489 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glycogen phosphorylase, muscle form as ChEMBL target CHEMBL4696, mapped to UniProt P00489. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glycogen phosphorylase, muscle form
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4696
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P00489
Glycogen phosphorylase, muscle form
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glycogen phosphorylase, muscle form is the right protein anchor across sources, using UniProt P00489 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlycogen phosphorylase, muscle form
UniProt AccessionP00489
Component TypeProtein
Sequence Length843 aa

Glycogen phosphorylase, muscle form

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glycogen phosphorylase, muscle form, mapped to UniProt P00489. Sequence length is 843 aa.

Mapped IDP00489
Review nameGlycogen phosphorylase, muscle form
OrganismOryctolagus cuniculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50727.0
KI329.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL114950 8.8 IC50 1.6 Preclinical
CHEMBL3323454 8.15 IC50 7.0 Preclinical
CHEMBL2030481 7.62 IC50 24.0 Preclinical
CHEMBL3770455 7.51 Ki 31.0 Preclinical
CHEMBL3323453 7.35 IC50 45.0 Preclinical
CHEMBL4101331 6.9 Ki 125.0 Preclinical
CHEMBL490175 6.8 Ki 160.0 Preclinical
CHEMBL3916767 6.75 IC50 178.0 Preclinical
CHEMBL1644919 6.68 IC50 210.0 Preclinical
CHEMBL3770514 6.65 Ki 226.0 Preclinical
Distribution

pChEMBL Value Distribution

139
5.0
51
5.5
24
6.0
8
6.5
2
7.0
2
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

120
Total Assays
603
Tested Compounds
1
Assay Types
Binding — 120 assays, 603 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 116 576 4.8
tissue-based format 4 27 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine