Nitric oxide synthase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Z0J4. Use UniProt Q9Z0J4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Z0J4 as the stable identity anchor, then attach disease evidence before program review.
Nitric oxide synthase 1
Review this target as Nitric oxide synthase 1, mapped to UniProt Q9Z0J4. Sequence length is 1429 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nitric oxide synthase 1 as ChEMBL target CHEMBL4719, mapped to UniProt Q9Z0J4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nitric oxide synthase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q9Z0J4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nitric oxide synthase 1 |
| UniProt Accession | Q9Z0J4 |
| Component Type | Protein |
| Sequence Length | 1429 aa |
Nitric oxide synthase 1
Review this target as Nitric oxide synthase 1, mapped to UniProt Q9Z0J4. Sequence length is 1429 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL594682 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL105792 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL480419 | 7.28 | Ki | 52.0 | Preclinical |
| CHEMBL447832 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL227744 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL106261 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL317459 | 6.17 | IC50 | 680.0 | Preclinical |
| CHEMBL320547 | 6.1 | IC50 | 790.0 | Preclinical |
| CHEMBL323117 | 6.07 | IC50 | 850.0 | Preclinical |
| CHEMBL108318 | 6.04 | IC50 | 920.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 24 | 5.7 |
| assay format | 2 | 19 | 5.1 |
| organism-based format | 2 | 0 | — |