Use UniProt O02747 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4725 Target Snapshot
Aryl hydrocarbon receptor · SINGLE PROTEIN · Oryctolagus cuniculus
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As of 2026-09-14Protein identity stays anchored to UniProt O02747. Use UniProt O02747 as the stable identity anchor, then attach disease evidence before program review.
Aryl hydrocarbon receptor
Review this target as Aryl hydrocarbon receptor, mapped to UniProt O02747. Sequence length is 847 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Aryl hydrocarbon receptor as ChEMBL target CHEMBL4725, mapped to UniProt O02747. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Aryl hydrocarbon receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
| UniProt | O02747 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aryl hydrocarbon receptor |
| UniProt Accession | O02747 |
| Component Type | Protein |
| Sequence Length | 847 aa |
Aryl hydrocarbon receptor
How to read this target
Review this target as Aryl hydrocarbon receptor, mapped to UniProt O02747. Sequence length is 847 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL179510 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL178733 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL179619 | 8.85 | Ki | 1.4 | Preclinical |
| CHEMBL361212 | 8.68 | Ki | 2.1 | Preclinical |
| CHEMBL179374 | 8.51 | Ki | 3.1 | Preclinical |
| CHEMBL179481 | 8.42 | Ki | 3.8 | Preclinical |
| CHEMBL175525 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL427498 | 8.24 | Ki | 5.7 | Preclinical |
| CHEMBL361541 | 8.17 | Ki | 6.8 | Preclinical |
| CHEMBL296411 | 8.11 | Ki | 7.7 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 2 assays, 25 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 25 | 7.9 |