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Target Snapshot

CHEMBL4725 Target Snapshot

Aryl hydrocarbon receptor · SINGLE PROTEIN · Oryctolagus cuniculus

25Compounds
2Assays
0Approved Drugs
25.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O02747. Use UniProt O02747 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O02747 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Aryl hydrocarbon receptor as ChEMBL target CHEMBL4725, mapped to UniProt O02747. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Aryl hydrocarbon receptor
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4725
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O02747
Aryl hydrocarbon receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Aryl hydrocarbon receptor is the right protein anchor across sources, using UniProt O02747 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAryl hydrocarbon receptor
UniProt AccessionO02747
Component TypeProtein
Sequence Length847 aa

Aryl hydrocarbon receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Aryl hydrocarbon receptor, mapped to UniProt O02747. Sequence length is 847 aa.

Mapped IDO02747
Review nameAryl hydrocarbon receptor
OrganismOryctolagus cuniculus
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

KI25.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL179510 9.7 Ki 0.2 Preclinical
CHEMBL178733 8.92 Ki 1.2 Preclinical
CHEMBL179619 8.85 Ki 1.4 Preclinical
CHEMBL361212 8.68 Ki 2.1 Preclinical
CHEMBL179374 8.51 Ki 3.1 Preclinical
CHEMBL179481 8.42 Ki 3.8 Preclinical
CHEMBL175525 8.3 Ki 5.0 Preclinical
CHEMBL427498 8.24 Ki 5.7 Preclinical
CHEMBL361541 8.17 Ki 6.8 Preclinical
CHEMBL296411 8.11 Ki 7.7 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
6
7.0
7
7.5
6
8.0
4
8.5
0
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
25
Tested Compounds
1
Assay Types
Binding — 2 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 25 7.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine