Melanin-concentrating hormone receptor 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q8JZL2. Use UniProt Q8JZL2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8JZL2 as the stable identity anchor, then attach disease evidence before program review.
Melanin-concentrating hormone receptor 1
Review this target as Melanin-concentrating hormone receptor 1, mapped to UniProt Q8JZL2. Sequence length is 353 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melanin-concentrating hormone receptor 1 as ChEMBL target CHEMBL4730, mapped to UniProt Q8JZL2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Melanin-concentrating hormone receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q8JZL2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melanin-concentrating hormone receptor 1 |
| UniProt Accession | Q8JZL2 |
| Component Type | Protein |
| Sequence Length | 353 aa |
Melanin-concentrating hormone receptor 1
Review this target as Melanin-concentrating hormone receptor 1, mapped to UniProt Q8JZL2. Sequence length is 353 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL557629 | 10.28 | Ki | 0.052 | Preclinical |
| CHEMBL538424 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL2032049 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL179501 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL196388 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL196599 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL190842 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL3670638 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL216192 | 8.48 | Ki | 3.3 | Preclinical |
| CHEMBL216192 | 8.3 | IC50 | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 27 | 8.2 |
| cell-based format | 3 | 32 | 7.0 |
| organism-based format | 2 | 0 | — |
| tissue-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 7 | 0 | — |
| cell-based format | 3 | 13 | 6.8 |