N6-adenosine-methyltransferase catalytic subunit · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q86U44. Use UniProt Q86U44 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q86U44 as the stable identity anchor, then attach disease evidence before program review.
N(6)-adenosine-methyltransferase catalytic subunit METTL3
Review this target as N6-adenosine-methyltransferase catalytic subunit, mapped to UniProt Q86U44. ChEMBL maps the protein component as N(6)-adenosine-methyltransferase catalytic subunit METTL3. Sequence length is 580 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats N6-adenosine-methyltransferase catalytic subunit as ChEMBL target CHEMBL4739695, mapped to UniProt Q86U44. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | N6-adenosine-methyltransferase catalytic subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q86U44 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | N(6)-adenosine-methyltransferase catalytic subunit METTL3 |
| UniProt Accession | Q86U44 |
| Component Type | Protein |
| Sequence Length | 580 aa |
N(6)-adenosine-methyltransferase catalytic subunit METTL3
Review this target as N6-adenosine-methyltransferase catalytic subunit, mapped to UniProt Q86U44. ChEMBL maps the protein component as N(6)-adenosine-methyltransferase catalytic subunit METTL3. Sequence length is 580 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5291234 | 8.85 | Kd | 1.4 | Preclinical |
| CHEMBL5396973 | 8.44 | IC50 | 3.63 | Preclinical |
| CHEMBL5438009 | 8.37 | IC50 | 4.23 | Preclinical |
| CHEMBL5405105 | 8.36 | IC50 | 4.35 | Preclinical |
| CHEMBL5425488 | 8.35 | IC50 | 4.44 | Preclinical |
| CHEMBL204656 | 8.32 | Kd | 4.79 | Approved |
| CHEMBL5077332 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5412324 | 8.25 | IC50 | 5.67 | Preclinical |
| CHEMBL5423596 | 8.24 | IC50 | 5.76 | Preclinical |
| CHEMBL5433144 | 8.24 | IC50 | 5.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 41 | 90 | 6.0 |
| single protein format | 16 | 323 | 7.3 |
| assay format | 3 | 366 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 7.8 |
| cell-based format | 1 | 1 | 5.8 |