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Target Snapshot

CHEMBL4739707 Target Snapshot

Zinc finger protein Aiolos · SINGLE PROTEIN · Homo sapiens

115Compounds
26Assays
3Approved Drugs
72.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UKT9. Use UniProt Q9UKT9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UKT9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Zinc finger protein Aiolos as ChEMBL target CHEMBL4739707, mapped to UniProt Q9UKT9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Zinc finger protein Aiolos
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4739707
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UKT9
Zinc finger protein Aiolos
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Zinc finger protein Aiolos is the right protein anchor across sources, using UniProt Q9UKT9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelZinc finger protein Aiolos
UniProt AccessionQ9UKT9
Component TypeProtein
Sequence Length509 aa

Zinc finger protein Aiolos

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Zinc finger protein Aiolos, mapped to UniProt Q9UKT9. Sequence length is 509 aa.

Mapped IDQ9UKT9
Review nameZinc finger protein Aiolos
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

EC5072.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3989927 9.0 EC50 1.0 Clinical
CHEMBL4170596 8.3 EC50 5.0 Preclinical
CHEMBL5618808 7.92 EC50 12.0 Preclinical
CHEMBL3989934 7.7 EC50 20.0 Clinical
CHEMBL43452 7.7 EC50 20.0 Approved
CHEMBL5430384 7.16 EC50 70.0 Preclinical
CHEMBL848 7.16 EC50 70.0 Approved
CHEMBL5620230 6.96 EC50 110.0 Preclinical
CHEMBL5417302 6.89 EC50 130.0 Preclinical
CHEMBL5412109 6.85 EC50 142.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
1
5.5
3
6.0
5
6.5
2
7.0
3
7.5
1
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

POMALIDOMIDE
CHEMBL43452
Approved 2013
LENALIDOMIDE
CHEMBL848
Approved 2005
THALIDOMIDE
CHEMBL468
Approved 1956
Assay Landscape

Assay Landscape

26
Total Assays
18
Tested Compounds
1
Assay Types
Binding — 26 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 26 18 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine