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Target Snapshot

CHEMBL4739844 Target Snapshot

Immunoglobulin lambda variable 6-57 · SINGLE PROTEIN · Homo sapiens

45Compounds
8Assays
0Approved Drugs
83.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt P01721. Use UniProt P01721 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P01721 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Immunoglobulin lambda variable 6-57 as ChEMBL target CHEMBL4739844, mapped to UniProt P01721. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Immunoglobulin lambda variable 6-57
SINGLE PROTEIN · Homo sapiens
As of 2026-09-15
ChEMBL target ID
CHEMBL4739844
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
P01721
Immunoglobulin lambda variable 6-57
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Immunoglobulin lambda variable 6-57 is the right protein anchor across sources, using UniProt P01721 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelImmunoglobulin lambda variable 6-57
UniProt AccessionP01721
Component TypeProtein
Sequence Length117 aa

Immunoglobulin lambda variable 6-57

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Immunoglobulin lambda variable 6-57, mapped to UniProt P01721. Sequence length is 117 aa.

Mapped IDP01721
Review nameImmunoglobulin lambda variable 6-57
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

EC5083.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4866500 8.41 EC50 3.9 Preclinical
CHEMBL4874211 8.39 EC50 4.1 Preclinical
CHEMBL4870683 8.33 EC50 4.7 Preclinical
CHEMBL4848583 8.31 EC50 4.9 Preclinical
CHEMBL4856046 8.26 EC50 5.5 Preclinical
CHEMBL4859730 7.87 EC50 13.5 Preclinical
CHEMBL4849658 7.58 EC50 26.2 Preclinical
CHEMBL4855805 7.55 EC50 27.9 Preclinical
CHEMBL4866739 7.53 EC50 29.8 Preclinical
CHEMBL4856361 7.34 EC50 46.0 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
14
5.5
12
6.0
17
6.5
7
7.0
6
7.5
8
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
75
Tested Compounds
1
Assay Types
Binding — 8 assays, 75 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 34 6.6
assay format 2 41 6.3
cell-free format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine