Cysteine protease · SINGLE PROTEIN · Leishmania donovani
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q95WR6. Use UniProt Q95WR6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q95WR6 as the stable identity anchor, then attach disease evidence before program review.
Cysteine protease
Review this target as Cysteine protease, mapped to UniProt Q95WR6. Sequence length is 394 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cysteine protease as ChEMBL target CHEMBL4751, mapped to UniProt Q95WR6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cysteine protease |
| Target Type | SINGLE PROTEIN |
| Organism | Leishmania donovani |
| UniProt | Q95WR6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cysteine protease |
| UniProt Accession | Q95WR6 |
| Component Type | Protein |
| Sequence Length | 394 aa |
Cysteine protease
Review this target as Cysteine protease, mapped to UniProt Q95WR6. Sequence length is 394 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL191881 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL296588 | 6.8 | IC50 | 160.0 | Clinical |
| CHEMBL204200 | 4.63 | IC50 | 23500.0 | Preclinical |
| CHEMBL204036 | 4.6 | IC50 | 24900.0 | Preclinical |
| CHEMBL426667 | 4.5 | IC50 | 31400.0 | Preclinical |
| CHEMBL381970 | 4.37 | IC50 | 43000.0 | Preclinical |
| CHEMBL426564 | 4.2 | IC50 | 62600.0 | Preclinical |
| CHEMBL222870 | 4.18 | IC50 | 65300.0 | Preclinical |
| CHEMBL224801 | 4.14 | IC50 | 72000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 11 | 5.0 |