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Target Snapshot

CHEMBL4758 Target Snapshot

Vascular endothelial growth factor receptor 3 · SINGLE PROTEIN · Mus musculus

3Compounds
8Assays
1Approved Drugs
3.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P35917. Use UniProt P35917 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35917 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Vascular endothelial growth factor receptor 3 as ChEMBL target CHEMBL4758, mapped to UniProt P35917. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Vascular endothelial growth factor receptor 3
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4758
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35917
Vascular endothelial growth factor receptor 3
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Vascular endothelial growth factor receptor 3 is the right protein anchor across sources, using UniProt P35917 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVascular endothelial growth factor receptor 3
UniProt AccessionP35917
Component TypeProtein
Sequence Length1363 aa

Vascular endothelial growth factor receptor 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Vascular endothelial growth factor receptor 3, mapped to UniProt P35917. Sequence length is 1363 aa.

Mapped IDP35917
Review nameVascular endothelial growth factor receptor 3
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1946170 8.82 IC50 1.5 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
2
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

REGORAFENIB
CHEMBL1946170
Approved 2012
Assay Landscape

Assay Landscape

8
Total Assays
1
Tested Compounds
2
Assay Types
Functional — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 4 0
Binding — 4 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 1 7.8
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine