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Target Snapshot

CHEMBL4777 Target Snapshot

Neuropeptide Y receptor type 1 · SINGLE PROTEIN · Homo sapiens

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3,101Compounds
315Assays
3Approved Drugs
3,399.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P25929. Use UniProt P25929 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P25929 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neuropeptide Y receptor type 1 as ChEMBL target CHEMBL4777, mapped to UniProt P25929. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neuropeptide Y receptor type 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4777
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P25929
Neuropeptide Y receptor type 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neuropeptide Y receptor type 1 is the right protein anchor across sources, using UniProt P25929 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeuropeptide Y receptor type 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP25929
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeuropeptide Y receptor type 1
UniProt AccessionP25929
Component TypeProtein
Sequence Length384 aa

Neuropeptide Y receptor type 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neuropeptide Y receptor type 1, mapped to UniProt P25929. Sequence length is 384 aa.

Mapped IDP25929
Review nameNeuropeptide Y receptor type 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC501,458.0
KI1,714.0
EC50197.0
KD30.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL269503 10.7 IC50 0.02 Preclinical
CHEMBL3747715 10.59 Kd 0.026 Preclinical
CHEMBL4746035 10.5 Ki 0.03162 Preclinical
CHEMBL508974 10.43 Ki 0.037 Preclinical
CHEMBL3559801 10.4 EC50 0.03981 Preclinical
CHEMBL5420881 10.32 EC50 0.0476 Preclinical
CHEMBL508974 10.3 IC50 0.05012 Preclinical
CHEMBL349328 10.28 Ki 0.052 Preclinical
CHEMBL4794692 10.28 Ki 0.05248 Preclinical
CHEMBL4746035 10.26 IC50 0.05495 Preclinical
Distribution

pChEMBL Value Distribution

181
5.0
85
5.5
122
6.0
132
6.5
148
7.0
114
7.5
97
8.0
76
8.5
52
9.0
71
9.5
pChEMBL
Assay Landscape

Assay Landscape

315
Total Assays
756
Tested Compounds
2
Assay Types
Binding — 247 assays, 756 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 121 67 7.0
cell-based format 119 665 7.4
assay format 4 13 6.5
cell membrane format 3 11 7.4
Functional — 68 assays, 275 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 39 175 6.1
assay format 29 100 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine