Endothelin-converting enzyme 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Endothelin-converting enzyme 1 shows clinical signal disease relevance led by hypertension. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P42892. Start with hypertension, then reuse UniProt P42892 as the stable protein anchor across project notes and exports.
Start with hypertension, then reuse UniProt P42892 as the stable protein anchor across project notes and exports.
Endothelin-converting enzyme 1 shows clinical signal disease relevance led by hypertension. 1 linked drug remains visible in the same block.
Start review with hypertension because it currently carries clinical signal support. Linked drugs include DAGLUTRIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEndothelin-converting enzyme 1
Review this target as Endothelin-converting enzyme 1, mapped to UniProt P42892. Sequence length is 770 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Endothelin-converting enzyme 1 as ChEMBL target CHEMBL4791, mapped to UniProt P42892. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Endothelin-converting enzyme 1 is the right protein anchor across sources, using UniProt P42892 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hypertension is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Endothelin-converting enzyme 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42892 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endothelin-converting enzyme 1 |
| UniProt Accession | P42892 |
| Component Type | Protein |
| Sequence Length | 770 aa |
Endothelin-converting enzyme 1
Review this target as Endothelin-converting enzyme 1, mapped to UniProt P42892. Sequence length is 770 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Endothelin-converting enzyme 1 shows clinical signal disease relevance led by hypertension.
Start review with hypertension because it currently carries clinical signal support. Linked drugs include DAGLUTRIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL66284 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL66967 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL303159 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL479579 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL571153 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL63317 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL147964 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL304939 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL303892 | 8.32 | IC50 | 4.8 | Preclinical |
| CHEMBL148056 | 8.22 | IC50 | 6.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 50 | 219 | 6.7 |
| cell-based format | 10 | 98 | 6.1 |
| tissue-based format | 6 | 41 | 6.5 |
| assay format | 2 | 14 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 1 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 5.3 |