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Target Snapshot

CHEMBL4793 Target Snapshot

Dipeptidyl peptidase 9 · SINGLE PROTEIN · Homo sapiens

1,671Compounds
151Assays
8Approved Drugs
1,848.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q86TI2. Use UniProt Q86TI2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q86TI2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dipeptidyl peptidase 9 as ChEMBL target CHEMBL4793, mapped to UniProt Q86TI2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dipeptidyl peptidase 9
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4793
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q86TI2
Dipeptidyl peptidase 9
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Dipeptidyl peptidase 9 is the right protein anchor across sources, using UniProt Q86TI2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDipeptidyl peptidase 9
UniProt AccessionQ86TI2
Component TypeProtein
Sequence Length863 aa

Dipeptidyl peptidase 9

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Dipeptidyl peptidase 9, mapped to UniProt Q86TI2. Sequence length is 863 aa.

Mapped IDQ86TI2
Review nameDipeptidyl peptidase 9
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
3
Phase III
Assay Mix

Activity Type Distribution

IC501,635.0
KI213.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL142703 9.92 IC50 0.12 Approved
CHEMBL1215376 9.72 Ki 0.19 Preclinical
CHEMBL1215374 9.55 Ki 0.28 Preclinical
CHEMBL2441845 9.52 Ki 0.3 Preclinical
CHEMBL1215375 9.52 Ki 0.3 Preclinical
CHEMBL2063040 9.51 IC50 0.31 Preclinical
CHEMBL67089 9.39 Ki 0.41 Preclinical
CHEMBL2441839 9.3 Ki 0.5 Preclinical
CHEMBL63860 9.28 Ki 0.53 Preclinical
CHEMBL1215236 9.26 Ki 0.55 Preclinical
Distribution

pChEMBL Value Distribution

136
5.0
135
5.5
76
6.0
58
6.5
65
7.0
18
7.5
32
8.0
29
8.5
16
9.0
6
9.5
pChEMBL
Approved Drugs

Approved Drugs

TENELIGLIPTIN
CHEMBL2147777
Approved 2012
SAXAGLIPTIN ANHYDROUS
CHEMBL385517
Approved 2009
VILDAGLIPTIN
CHEMBL142703
Approved 2007
Assay Landscape

Assay Landscape

151
Total Assays
810
Tested Compounds
2
Assay Types
Binding — 146 assays, 810 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 108 611 5.7
cell-based format 31 105 6.8
assay format 7 94 5.3
ADME — 5 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 1 7.3
cell-based format 1 1 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine