Caspase-1 · SINGLE PROTEIN · Mus musculus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-15Protein identity stays anchored to UniProt P29452. Use UniProt P29452 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29452 as the stable identity anchor, then attach disease evidence before program review.
Caspase-1
Review this target as Caspase-1, mapped to UniProt P29452. Sequence length is 402 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Caspase-1 as ChEMBL target CHEMBL4800, mapped to UniProt P29452. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Caspase-1 is the right protein anchor across sources, using UniProt P29452 as the stable mapping.
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| Preferred Name | Caspase-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P29452 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Caspase-1 |
| UniProt Accession | P29452 |
| Component Type | Protein |
| Sequence Length | 402 aa |
Caspase-1
Review this target as Caspase-1, mapped to UniProt P29452. Sequence length is 402 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3944828 | 8.85 | Ki | 1.4 | Preclinical |
| CHEMBL3934331 | 8.74 | Ki | 1.8 | Preclinical |
| CHEMBL330110 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL3951248 | 8.41 | Ki | 3.9 | Preclinical |
| CHEMBL330534 | 8.35 | Ki | 4.5 | Preclinical |
| CHEMBL2370217 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL315868 | 8.32 | Ki | 4.8 | Preclinical |
| CHEMBL91281 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL1199647 | 8.28 | Ki | 5.3 | Preclinical |
| CHEMBL194207 | 8.28 | Ki | 5.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 12 | 105 | 7.4 |
| cell-based format | 5 | 0 | — |